In Vitro Degradation Behavior of Microspheres Based on Cross-Linked Dextran

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The Mucosal Adjuvant Potential of Cross-Linked Dextran Microspheres as Dry Powder

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Mucosal Adjuvant Potential of Quillaja saponins and Cross-linked Dextran Microspheres, Co-administered with Liposomes Encapsulated with Tetanus Toxoid

Intranasal vaccination is particularly a striking route for mucosal immunization, due to the ease of administration and the induction of both mucosal and humoral immunity. However, soluble antigens (Ag) are not sufficiently taken up after the nasal administration and need to be co-administered with adjuvants, penetration enhancers or encapsulated in particles. So, in this study, tetanus toxoid ...

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the mucosal adjuvant potential of cross-linked dextran microspheres as dry powder

objective(s) the immunoadjuvant potential of cross-linked dextran microspheres (cdm) as absorption enhancer and quillaja saponins (qs) as immunomodulator adjuvant was evaluated. materials and methods cdm loaded or tetanus-mixed toxoid (tt) or quillaja saponin (qs) were nasally administered to rabbits in dry powder form, three times in 2 weeks interval and serum igg and nasal lavage siga titers ...

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ژورنال

عنوان ژورنال: Biomacromolecules

سال: 2006

ISSN: 1525-7797,1526-4602

DOI: 10.1021/bm060385z